Hydrogen Isotope Labeling of Pharmaceuticals Via Dual Hydrogen Isotope Exchange Pathways Using CdS Quantum Dot Photocatalyst.

Isotopic labeling is a powerful technique extensively used in the pharmaceutical industry. By tracking isotope-labeled molecules, researchers gain unique and invaluable insights into the pharmacokinetics and pharmacodynamics of new drug candidates. Hydrogen isotope labeling is particularly important as hydrogen is ubiquitous in organic molecules in biological systems, and it can be introduced effectively through late-stage hydrogen isotope exchange (HIE).

Community-Engaged Approaches for Improving the Inclusion of Diverse Communities in a Nutrition Clinical Trial.

Background: Cardiometabolic disease (CMD) disproportionately affects African American/Black (AA) and Latino communities. CMD disparities are exacerbated by their underrepresentation in clinical trials for CMD treatments including nutritional interventions. The study aimed to (1) form a precision nutrition community consultant panel (PNCCP) representative of Latino and AA communities in Los Angeles to identify barriers and facilitators to recruitment and retention of diverse communities into nutrition clinical trials and (2) develop culturally informed strategies to improve trial diversity.

The Neuropeptide Substance P is Elevated in Sickle Cell Disease and is a Marker of Severity of Vaso-occlusive Crisis.

Background: Acute episode of pain is the most frequent symptom for which patients with sickle cell disease (SCD) seek medical attention. The neuropeptide Substance P (SP) has been suggested as a possible aetiologic factor. This study compared the serum levels of SP in SCD subjects in painful vaso-occlusive crisis with those in steady state and normal HbAA subjects.

Predictors of cervical cancer screening service utilization among female health care workers in a tertiary hospital in Osogbo, Osun State.

Cervical cancer is the second commonest cancer in Nigerian women that can be reduced through effective screening. This study aimed to determine the utilization of cervical cancer screening services among female health care workers in a tertiary hospital. It is a descriptive cross-sectional study that utilized a pretested questionnaire to collect data from 170 respondents.

Prevalence, Pattern and Factors Associated with Online Sexual Activity among Final Year Students in Osun State University, Nigeria.

Background: The internet has opened up new avenues for sexual exploration, including online sexual activity (OSA), which is becoming increasingly common among young adults globally. This study aimed to investigate the prevalence, patterns, and associated factors of OSA among final-year students in Osun State University, Nigeria.

Methods: A descriptive cross-sectional study was carried out among 436 undergraduates.