Publications by authors named "M O'Guinn"
Objective: To evaluate outcomes and postoperative complications following surgical resection of lymphatic malformations (LMs) at a single multidisciplinary vascular anomalies center.
Methods: A single-center retrospective review of all patients ≤21 years old who underwent surgical resection of a lymphatic malformation at a quaternary referral center with a multidisciplinary vascular anomalies team from 2004 to 2024. Data pertaining to postoperative outcomes and treatments was abstracted.
Article Synopsis
- During the COVID-19 pandemic, many kids with appendicitis were treated without surgery at first but later had surgery called appendectomy.
- The study looked at children under 21 who had this surgery at certain hospitals from March 2020 to July 2022, comparing those with COVID-19 to those without.
- Results showed that kids with COVID-19 had shorter hospital stays and fewer complications after surgery compared to those without COVID-19.
Objective: Traumatic injuries are a leading cause of death in children and a child's neighborhood characteristics can be a risk factor. Our objective was to describe the association between pediatric trauma mortality and Child Opportunity Index (COI).
Methods: A multicenter, retrospective cross-sectional study was conducted across 15 trauma centers from 2010 to 2021 within a large metropolitan county to evaluate trauma activation mortalities involving children <18 years-old.
Background: Traumatic brain injury (TBI) is a common injury in children. Previous literature has demonstrated that TBI may be associated with supervision level. We hypothesised that primary caregiver employment would be associated with child TBI.
View Article and Find Full Text PDFFXR deletion attenuates intestinal barrier dysfunction in murine acute intestinal inflammation.
Am J Physiol Gastrointest Liver Physiol
August 2024
Accumulating literature suggests that the farnesoid-X receptor (FXR), a nuclear bile acid receptor best known for its role in bile acid homeostasis, is also a potent context-dependent regulator of inflammation. FXR may thus be relevant to several intestinal disease states including inflammatory bowel disease, necrotizing enterocolitis, and sepsis. In this study, we tested the effects of FXR deletion on acute murine intestinal inflammation.
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