Background and objective Alveolar ridge defects in partially edentulous patients present significant challenges in prosthodontic treatment planning. Seibert's classification system provides a structured approach to categorizing these defects based on the buccolingual and apico-coronal dimensions of the ridge. Accurate classification is crucial for determining appropriate treatment strategies for implant placement, fixed prosthesis, or tissue augmentation.
View Article and Find Full Text PDFGenetic risk variants for common diseases are predominantly located in non-coding regulatory regions and modulate gene expression. Although bulk tissue studies have elucidated shared mechanisms of regulatory and disease-associated genetics, the cellular specificity of these mechanisms remains largely unexplored. This study presents a comprehensive single-nucleus multi-ancestry atlas of genetic regulation of gene expression in the human prefrontal cortex, comprising 5.
View Article and Find Full Text PDFMucolipidosis type IV (MLIV) is classified as an exceptionally autosomal recessive condition due to a change in MCOLN1 that encodes the mucolipin-1 protein. ML-1 is a membrane protein comprising 6 Trans regions, which are situated at the LELs, a serine lipase area, and a nuclear localization sign. The characteristic features of the ML4 patients are mental retardation and skeletal deformities due to an increase in lipid molecules in the brain, other tissues, and organs.
View Article and Find Full Text PDFRising temperature due to changing climate significantly impacts the production of tomato. The morpho-physiological functions of tomato such as gas exchange, growth and development, flowering, fruit setting, quality, fruit size, weight that can influence the yield and production is drastically affected by higher temperatures. Among the growth stages of tomato, flowering and fruit setting stage is highly vulnerable to high temperature resulting in reduced flower numbers, increased flower abortion, stigma exertion, abnormal ovule, reduced pollen germination, pollen numbers, pollen tube development, pollen viability and increased male sterility.
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