Compliance of clinical trial registries with the World Health Organization minimum data set: a survey.

Background: Since September 2005 the International Committee of Medical Journal Editors has required that trials be registered in accordance with the World Health Organization (WHO) minimum dataset, in order to be considered for publication. The objective is to evaluate registries' and individual trial records' compliance with the 2006 version of the WHO minimum data set.

Methods: A retrospective evaluation of 21 online clinical trial registries (international, national, specialty, pharmaceutical industry and local) from April 2005 to February 2007 and a cross-sectional evaluation of a stratified random sample of 610 trial records from the 21 registries.

Oral versus intra-vaginal imidazole and triazole anti-fungal treatment of uncomplicated vulvovaginal candidiasis (thrush).

Background: Anti-fungals are available for oral and intra-vaginal treatment of uncomplicated vulvovaginal candidiasis (thrush).

Objectives: The primary objective of this review was to assess the relative effectiveness of oral versus intra-vaginal anti-fungals for the treatment of uncomplicated vulvovaginal candidiasis. The secondary objectives of the review were to assess the cost-effectiveness, safety and patient preference of oral versus intra-vaginal anti-fungals.

Will chromosome karyotyping of meningiomas aid prediction of tumour recurrence?

Cytogenetic studies over many years have established absence or deletion of chromosome 22 as a common finding in meningiomas. Enormous karyotypic variation is recognised: an abnormal hyperdiploid clone can occur in a histologically benign meningioma. The cytogenetic, histopathological and macroscopic findings in 13 meningiomas of a prospective study are presented.

Infantile hypothalamic hamartoma with multiple congenital abnormalities.

This case report describes a hypothalamic hamartoma with multiple congenital abnormalities in a male infant, with a post-mortem examination and histology of the lesion.