Publications by authors named "M Nordine"
Introduction: Goal-directed fluid therapy (GDFT) has been shown to reduce postoperative complications. The feasibility of GDFT in transcatheter aortic valve replacement (TAVR) patients under general anesthesia has not yet been demonstrated. We examined whether GDFT could be applied in patients undergoing TAVR in general anesthesia and its impact on outcomes.
View Article and Find Full Text PDFBackground: Beta-blocker (BB) therapy plays a central role in the treatment of cardiovascular diseases. An increasing number of patients with cardiovascular diseases undergoe noncardiac surgery, where opioids are an integral part of the anesthesiological management. There is evidence to suggest that short-term intravenous BB therapy may influence perioperative opioid requirements due to an assumed cross-talk between G-protein coupled beta-adrenergic and opioid receptors.
View Article and Find Full Text PDFBackground: Peri-operative and critically ill patients often experience mild to moderate hypovolaemic shock with preserved mean arterial pressure (MAP), heart rate (HR) and decreased stroke volume index (SVI).
Objectives: The aim of this study was to evaluate echocardiographic parameters during simulated mild to moderate central hypovolaemia.
Design: This was a prospective preclinical study.
Article Synopsis
- Orthostatic dysregulation can happen when people return to normal gravity after being in microgravity, which is common in space travel; external peripheral skin cooling (PSC) has been proposed as a potential solution to this issue.
- A study called "Coolspin" was conducted with 18 healthy male volunteers, testing PSC while subjected to increased gravitational forces (up to +4g) in a centrifuge, measuring various cardiovascular parameters.
- The results showed that PSC did not significantly improve cardiovascular stability or hemodynamic activity during +Gz, suggesting that the cooling method used may not have been adequate or the subjects' responses to cooling were low, indicating a need for further research.
Background: To implement a goal-directed fluid therapy (GDFT) protocol using crystalloids in hip revision arthroplasty surgery within a quality management project at a tertiary hospital using a monocentric, prospective observational study.
Methods: Adult patients scheduled for elective hip revision arthroplasty surgery were screened for inclusion in this prospective study. Intraoperatively stroke volume (SV) was optimized within a previously published protocol using uncalibrated pulse contour analysis and balanced crystalloids.