Publications by authors named "M Nogler"

Background: Cementoplasty has been successfully used for treating fractures in various parts of the human body, although the use in weight-bearing long bones is a subject of controversial debate. Strategies to improve the mechanical properties of polymethylmethacrylate-based bone cement (BC) comprise changing the chemical composition or the application of metal reinforcement strategies. In clinical practice reinforced bone cement is used despite biomechanical basic research regarding this topic being scare.

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: This study evaluated the learning curve for robotic-assisted total knee arthroplasty (RA TKA) performed by three experienced surgeons, focusing on procedure duration, surgeon satisfaction, and confidence. A prospective study was conducted with three senior arthroplasty surgeons, each performing 15 RA TKA procedures using the Triathlon Knee System with the Robotic Arm Interactive Orthopedic (RIO) System. Data on preparation, cut-to-suture, and breakdown times were collected.

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Massive bone loss poses a significant challenge in defect reconstruction. The use of compacted allografts is a valuable technique to reconstruct bone stock. This study aimed to assess the impact of compression on the microstructure of native cancellous bone chips with a micro-CT analysis.

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Article Synopsis
  • Melanoma is a stubborn skin cancer that resists treatments like immunotherapy and can cause severe side effects.
  • Nitric oxide (NO) shows promise as a treatment due to its anticancer effects, low resistance potential, and reduced toxicity to healthy cells.
  • Research on three macromolecular NO donors demonstrated that NO payload is key for killing melanoma cells, while the type of donor significantly affects healthy cell toxicity; using a Pluronic F127 organogel enhanced delivery and effectiveness in reducing tumor growth in tests.
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The increasing numbers of total joint replacements and related implant-associated infections demand solutions, which can provide a high-dose local delivery of antibiotics. Antibiotic-loaded bone cement (ALBC) is an accepted treatment method for infected joint arthroplasties. The mechanical properties of low-dose gentamicin-loaded bone cement (BC) in medium- and high-viscosity versions were compared to unloaded BC using a vacuum mixing system.

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