Publications by authors named "M Nobrega"
Comparative analysis of extracellular vesicles miRNAs (EV-miRNAs) and cell-free microRNAs (cf-miRNAs) reveals that EV-miRNAs are more promising as diagnostic and prognostic biomarkers for prostate cancer.
Gene
March 2025
MicroRNAs can be found intracellularly incorporated into extracellular vesicles (EV-miRNAs) or extracellularly as cell-free miRNAs (cf-miRNAs). This study aimed to compare the diagnostic and prognostic potential of four miRNAs with recognized roles in prostate cancer as cf-miRNAs and EV-miRNAs, obtained from liquid biopsies (LB). Total RNA was isolated from whole plasma and plasma EVs from 15 controls (CTR) and 30 patients (20 with localized prostate cancer (PCa), 10 with metastatic prostate cancer (mPCa)).
View Article and Find Full Text PDFIntroduction: Cognitive deficits in acquired brain injury patients, particularly in domains like attention, memory, executive function, and social cognition, affect patients' quality of life. While rehabilitation strategies often focus on conventional methods, emerging technologies like Virtual Reality and computerized cognitive training offer new approaches. This study explores the efficacy of a tablet-based cognitive training program and the use of Virtual Reality for social cognition assessment .
View Article and Find Full Text PDFArticle Synopsis
- The study analyzes the safety and surveillance measures of the mpox (Jynneos) vaccine in Brazil between 2022 and 2023, focusing on reported cases and events linked to vaccination.
- Out of 49,000 doses distributed, 14,395 (31%) were administered, leading to 65 reported non-serious events supposedly connected to the vaccine, equivalent to 4.5 events per 1,000 doses.
- The findings indicate that while the events were within expected limits, further monitoring is crucial, particularly for high-risk groups, to ensure the vaccine's safety and effectiveness.
Article Synopsis
- - From March 2023 to March 2024, a study was conducted in Brazil to analyze cases of anaphylaxis following the Attenuated Dengue Vaccine (TAK-003), where 380,358 doses were administered and 626 adverse events were reported.
- - Out of the reported adverse events, 85 were cases of immediate hypersensitivity, with 24 confirmed cases of anaphylaxis, three of which were categorized as anaphylactic shock, and most reactions occurred within 15 minutes post-vaccination.
- - In response to the increased occurrence of anaphylaxis after the vaccine, Brazil’s Ministry of Health recommended enhanced safety measures, including additional training for healthcare professionals and observation protocols after vaccination. *