Does Undertreatment With Chemotherapy Impact the Outcomes of Elderly Patients With Early-Stage Breast Cancer? A Real-World Data Analysis.

Background: The management of breast cancer (BC) in elderly patients remains a topic of debate among specialists, with concerns regarding potential undertreatment. This study aimed to evaluate the impact of undertreatment on outcomes in older patients with early-stage BC.

Methods: This retrospective cohort study analyzed patients aged over 70 years with early breast cancer who were treated at an academic cancer center between 2009 and 2021.

Metabolic response of Zostera noltei transplants in a historically contaminated ecosystem.

In the midst of the UN Decade on Ecosystem Restoration and newly approved EU Nature Restoration Law, ecosystem restoration efforts have gained momentum. Still, monitoring tools and early warning protocols to evaluate restoration success are necessary. This study aimed to assess the suitability of using biochemical response parameters to evaluate Z.

Impacts of Yacon Syrup () on Human Health: A Systematic Review of Scientific Evidence from the Last Decade.

Background/objectives: Yacon syrup () has gained attention due to its high concentration of fructooligosaccharides (FOSs) and associated health benefits. This systematic review aimed to evaluate the effects of yacon syrup on metabolic parameters and intestinal health in humans over the last decade.

Methods: Following PRISMA guidelines, we conducted a systematic search in databases, including Medline (PubMed), Science Direct, Embase, Scopus, and SciELO, up to October 2024.

Drug-Checking and Monitoring New Psychoactive Substances: Identification of the U-48800 Synthetic Opioid Using Mass Spectrometry, Nuclear Magnetic Resonance Spectroscopy, and Bioinformatic Tools.

The misuse of opioids and opiates has remained a persistent issue since the 19th century. The recent resurgence of non-fentanyl synthetic opioids, such as U-type opioids and nitazenes, has further exacerbated the ongoing crisis. Identifying these synthetic opioids presents many challenges, including the emergence of new substances, the lack of standards, and the presence of structural isomers.

Seagrass biochemical response to transplantation into contaminated sediments: A mesocosm experiment.

Efforts to remediate and restore degraded ecosystems through Nature-based Solutions (NbS) have intensified during the United Nations Decade for Ecosystem Restoration (2021-2030). To evaluate the potential of seagrass transplantation for recovering historically contaminated areas, a mesocosm experiment was performed with the following objectives: 1) assess the suitability of the transplant method; 2) evaluate the tolerance of Zostera noltei to different concentrations of metal(loid)s in sediments; 3) clarify the tolerance mechanisms and measure oxidative stress levels and energy budget across different tissues and sampling times; and 4) investigate its potential as a Nature-based Solution. Results demonstrated that seagrass could tolerate various concentrations of metal(loid)s in sediments and activate mechanisms to reduce oxidative stress, without interfering with its growth and seasonal life cycle.