Publications by authors named "M Nitulescu"
Type 2 diabetes is associated with cardiovascular disease, possibly due to impaired vascular fibrous repair. Yet, the mechanisms are elusive. Here, we investigate alterations in the fibrous repair processes in type 2 diabetes atherosclerotic plaque extracellular matrix by combining multi-omics from the human Carotid Plaque Imaging Project cohort and functional studies.
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- The immune system plays a crucial role in cardiovascular health, particularly in relation to inflammation and its impact on heart disease.
- Atherosclerosis is characterized by lipid-driven inflammation, where macrophages are key players; however, recent research indicates that there are different macrophage states associated with lipids and inflammation.
- This study identifies a specific type of macrophage linked to cerebrovascular events and suggests that targeting these inflammatory lipid-associated macrophages could be a new treatment approach for cardiovascular disease.
Article Synopsis
- - The text is a correction relating to a previously published article.
- - It specifically addresses issues found in the original article identified by the DOI 10.1038/s44161-023-00295-x.
- - This correction is essential for ensuring the accuracy and integrity of the published research.
Aims: Inflammation is a key factor in atherosclerosis. The transcription factor interferon regulatory factor-5 (IRF5) drives macrophages towards a pro-inflammatory state. We investigated the role of IRF5 in human atherosclerosis and plaque stability.
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