Publications by authors named "M Nielsen"
Aim: To describe the use of invasive mechanical ventilation core strategies, adjuvant treatments and the occurrence of barotrauma and prolonged ventilation in ICU patients with COVID-19 in Denmark, retrospectively.
Methods: All ICUs admitting COVID-19 patients in Denmark from 10 March 2020 to 2 April 2021 were invited to participate. All patients with COVID-19 who received invasive mechanical ventilation were included and data was retrospectively collected from electronic patient records.
Artificial Intelligence and Machine Learning (AI/ML) techniques, including reverse vaccinology and predictive models, have already been applied for developing vaccine candidates for COVID-19, HIV, and Hepatitis, streamlining the vaccine development lifecycle from discovery to deployment. The application of AI and ML technologies for improving heath interventions, including drug discovery and clinical development, are expanding across Africa, particularly in South Africa, Kenya, and Nigeria. Further initiatives are required however to expand AI/ML capabilities across the continent to ensure the development of a sustainable ecosystem including enhancing the requisite knowledge base, fostering collaboration between stakeholders, ensuring robust regulatory and ethical frameworks and investment in requisite infrastructure.
View Article and Find Full Text PDFObjective: To describe the clinical features and outcome of brain abscess since introduction of computerized tomography and magnetic resonance imaging.
Methods: MEDLINE and Embase were searched using "brain abscess" or "cerebral abscess" from 1970 through 2023 and analyses restricted to study populations hospitalized after 1980. Single-variable meta-analyses were done using a random-effects model.
Article Synopsis
- Safe and Sustainable by Design (SSbD) is a new regulatory approach aimed at guiding the development of chemicals and materials, recommended by the European Commission with a focus on a two-stage framework.
- The SSbD process involves setting principles for redesigning materials and assessing their safety and sustainability, but its effectiveness for advanced materials like TiCT MXenes still needs further exploration.
- Research on TiCT MXenes indicates they are safe and sustainable under the SSbD framework, but more studies are required on their long-term effects and the eco-friendly production of titanium, as well as guidance on evaluating the relevant evidence for SSbD assessments.