Publications by authors named "M Nicholas Coppola"
Although people who inject drugs (PWID) are at high risk of acquiring HIV, knowledge and uptake of pre-exposure prophylaxis (PrEP) for HIV prevention among this population remain low due to numerous psychosocial and structural barriers. Multiple implementation strategies have been proposed to address this gap, notably providing long-acting injectable (LAI) formulations of PrEP and offering PrEP at syringe services programs (SSPs). This qualitative study explores the acceptability and feasibility of offering LAI-PrEP for PWID at risk for HIV at Florida's first legal SSP.
View Article and Find Full Text PDFStudies of homesigns have shed light on the human capacity for language and on the challenging problem of language acquisition. The study of homesign has evolved from a perspective grounded in gesture studies and child development to include sign language linguistics and the role of homesigns in language emergence at the community level. One overarching finding is that homesigns more closely resemble sign languages used by linguistic communities than they resemble the gestures produced by hearing people along with spoken language.
View Article and Find Full Text PDFObjective: To report our 3-year institutional experience of total laparoscopic (TL) segmental sigmoid colon/rectal resection for treatment of bowel endometriosis (BE).
Design: The TrEnd trial is a single-institutional retrospective/prospective study conducted with the aim of systematically collecting data from consecutive patients undergoing segmental colorectal resection for BE. This paper reports the outcomes of patients undergoing intracorporeal anastomosis and transanal natural orifice specimen extraction (NOSE) from this database.
Article Synopsis
- The CheckMate-743 trial showed that nivolumab plus ipilimumab improves overall survival in patients with unresectable pleural mesothelioma compared to chemotherapy, but lacked representation of Latin American patients.
- A retrospective study evaluated this treatment's effectiveness and safety in 96 LATAM patients, focusing on their demographic and clinical characteristics, with a median follow-up of 24.1 months.
- Results indicated median progression-free survival of 8 months and overall survival of 22 months, confirming treatment benefits similar to other findings, with manageable adverse events reported.
Article Synopsis
- The study identifies TMEM9B, a newly discovered protein that interacts specifically with the endosomal Cl transporters ClC-3 and ClC-4, affecting their activity.
- Co-expression experiments revealed that TMEM9B significantly reduces the functionality of ClC-3 and ClC-4 in certain cell models, but has minimal impact on other transporters.
- This research highlights the potential importance of TMEM9B in regulating neuronal endosomal processes and understanding diseases related to these chloride channels.