Anti-inflammatory and antishock water-soluble polyesters of glucocorticoids with low level systemic toxicity.

Purpose: The objective of this study was to evaluate the pharmacological activity of glucocorticoid hormones incorporated into the structure of water-soluble carbochain polymers via the esterified 21-CH2OH group.

Methods: Polymer analogs of glucocorticoids were prepared by radical copolymerization of 1-vinyl-2-pyrrolidone with cortisol or dexamethasone 21-crotonates and crotonic acid or 2-(diethylamino) ethylcrontonate which served as ionogenic comonomers. Anti-inflammatory, immunosuppressive and catabolic activities for ionogenic tertiary copolymers and previously prepared non-ionogenic binary copolymers were evaluated in standard animal models.

[The current concepts of the humoral mechanisms of the analgetic and antipyretic actions of acupuncture (a review of the literature)].

Needling triggers adaptive mechanisms, this feature determining a broad range of effects directed towards correction of disturbances in the homeostatic systems of the body. At present peripheral and central levels of response to needling are recognized. In a review of the published literature mechanisms are discussed of analgetic and antipyretic effects of acupuncture based on the latest findings in the field of neurochemistry.

Effect of naloxone on the antipyretic action of acupuncture.

The effect of the opioid antagonist naloxone on the antipyretic action of acupuncture was studied in rabbits. Naloxone (0.1-0.

[Evaluation of the antipyretic action of psychotropic drugs and their effect on the antipyretic effect of acupuncture therapy].

The effect of psychotropic agents on antipyretic effect of acupuncture was studied in rabbits with experimental fever. Haloperidol in the dosage 0.5 mg/kg and benactyzine in the dosage 0.