Publications by authors named "M Neville"
Article Synopsis
- - The relationship between the nucleus and cell cycle changes during cancer progression causes genomic instability, which tumor cells exploit to avoid cell death and treatment resistance.
- - In epithelial ovarian cancer, the overexpression of claudin-4 is linked to increased therapy resistance and helps stabilize the genome by modifying both the nuclear structure and the cell cycle dynamics.
- - Intervention using a claudin mimic peptide and forskolin shows that disrupting claudin-4 enhances the effectiveness of PARP inhibitors by altering the oxidative stress response and impacting genomic stability.
Latin American Surgical Outcomes Study in Paediatrics (LASOS-Peds): study protocol and statistical analysis plan for a multicentre international observational cohort study.
Vinícius Caldeira Quintão Gabriel Soares de Sousa Alexandra Torborg Alexandra Vieira Francesco Consonni Mariana Neville
BMJ Open
September 2024
Article Synopsis
- Access to safe surgery is a human right, but significant disparities exist between high-income and low-to-middle-income countries in terms of surgical care.* -
- The LASOS-Peds study is a 14-day international research project exploring the rates of complications after pediatric surgeries in Latin America, focusing on both elective and emergency cases.* -
- Approved by an Institutional Review Board, the findings will be published in peer-reviewed journals and shared at international conferences, with the aim of improving pediatric surgical outcomes.*
During cancer development, the interplay between the nucleus and the cell cycle leads to a state of genomic instability, often accompanied by observable morphological aberrations. These aberrations can be controlled by tumor cells to evade cell death, either by preventing or eliminating genomic instability. In epithelial ovarian cancer (EOC), overexpression of the multifunctional protein claudin-4 is a key contributor to therapy resistance through mechanisms associated with genomic instability.
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- Genome-wide association studies have found numerous genetic loci linked to glycemic traits, but connecting these loci to specific genes and biological pathways remains a challenge.
- Researchers conducted meta-analyses of exome-array studies across four glycemic traits, analyzing data from over 144,000 participants, which led to the identification of coding variant associations in more than 60 genes.
- The study revealed significant pathways related to insulin secretion, zinc transport, and fatty acid metabolism, enhancing understanding of glycemic regulation and making data available for further research.
Article Synopsis
- Meiotic recombination is crucial for genetic diversity, involving both crossovers and non-crossover events that lead to gene conversion.
- Researchers used long sequencing reads from sperm samples to analyze recombination events, highlighting variability between and within male donors.
- The study found non-crossover gene conversions often occur near PRDM9 binding sites, suggesting two distinct mechanisms: one common, linked to PRDM9, and another rarer, associated with complex genetic events.