Publications by authors named "M Neunlist"
Enteric Glial Cells at the Crossroads Between Intestinal Inflammation and Amyloids Diseases.
Cell Mol Gastroenterol Hepatol
July 2024
The neural network of the enteric nervous system (ENS) underlies gastrointestinal functions. However, the molecular mechanisms involved in enteric neuronal connectivity are poorly characterized. Here, we studied the role of semaphorin 5A (Sema5A), previously characterized in the central nervous system, on ENS neuronal connectivity.
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- This pilot study aimed to see if confocal laser endoscopy (CLE) can help identify certain cells (α4β7- and TNF-expressing) that could predict how well ulcerative colitis patients respond to the drug vedolizumab.
- Nineteen patients with moderate-to-severe ulcerative colitis participated, and 58% showed clinical and endoscopic improvement after treatment, with specific staining patterns indicating potential responders versus non-responders.
- The findings suggest that positive α4β7 staining detected through CLE could be linked to better treatment outcomes, although blood tests and immune cell counts did not correlate with patient responses.
Background & Aims: The presence of myenteric plexitis in the proximal resection margins is a predictive factor of early postoperative recurrence in Crohn's disease. To decipher the mechanisms leading to their formation, T-cell interactions with enteric neural cells were studied in vitro and in vivo.
Methods: T cells close to myenteric neural cells were retrospectively quantified in ileocolonic resections from 9 control subjects with cancer and 20 patients with Crohn's disease.
Introduction: Intestinal manipulation (IM)-induced inflammation could contribute to postoperative ileus (POI) pathophysiology via the modulation of prostanoid pathways. To identify the prostanoids involved, we aimed to characterize the profile of prostanoids and their synthesis enzyme expression in a murine model of POI and to determine whether the altered prostanoids could contribute to POI.
Methods: Four or 14 h after IM in mice, gastrointestinal (GI) motility and intestinal epithelial barrier (IEB) permeability were assessed in vivo and ex vivo in Ussing chambers.