Publications by authors named "M Neuenfeld"
Article Synopsis
- The study examined how hydrogen peroxide affects enzyme activity in endothelial cells from pig aorta.
- An isolated segment of the pig aorta was perfused for 10 hours with varying amounts of hydrogen peroxide added to the medium.
- The presence of hydrogen peroxide gradually inhibited non-specific esterase activity in the endothelial cells, eventually leading to complete inactivation.
The effect of peroxides on the vascular endothelium of isolated pig aorta in vitro.
Exp Toxicol Pathol
January 1995
The effect of peroxide on endothelial cells (perfused pig aorta) was examined using an in vitro perfusion model. Hydrogen peroxide was added to the perfusion medium (pig serum together with a buffer solution) which was expected to lead to an increased oxidation of lipids and lipoproteins. Oxidation processes of this type play a decisive role in the pathogenesis and progression of arteriosclerosis.
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