Publications by authors named "M Neary"
Favipiravir (FVP) and remdesivir (RDV) have demonstrable antiviral activity against SARS-CoV-2. Here, the efficacy of FVP, RDV, and FVP with RDV (FVP + RDV) in combination was assessed in Syrian golden hamsters challenged with SARS-CoV- 2 (B.1.
View Article and Find Full Text PDFObjective: After Fontan palliation, patients with single-ventricle physiology are committed to chronic circulatory inefficiency for the duration of their lives. This is due in large part to the lack of a subpulmonary ventricle. A low-pressure rise cavopulmonary assist device can address the subpulmonary deficit and offset the Fontan paradox.
View Article and Find Full Text PDFBidentate N-ligands are paramount to recent advances in nickel-catalyzed cross-coupling reactions. Through comprehensive organometallic, spectroscopic, and computational studies on bi-oxazoline and imidazoline ligands, we reveal that a square planar geometry enables redox activity of these ligands in stabilizing nickel radical species. This finding contrasts with the prior assumption that bi-oxazoline lacks redox activity due to strong mesomeric donation.
View Article and Find Full Text PDFArticle Synopsis
- Global policymakers generally advise against using existing monoclonal antibodies like Ronapreve for COVID-19 treatment due to their reduced effectiveness against newer variants, especially Omicron.
- A study using K18-hACE2 mice showed that Ronapreve effectively reduced viral replication in the lungs and nasal areas for the Delta variant, but not for Omicron, and it prevented brain infection from Delta.
- Results indicated that Ronapreve alters the inflammatory response to the Delta variant, suggesting that while animal models can simulate treatment use cases, caution is needed in interpreting their relevance to actual treatment scenarios, particularly for Omicron.
Background: We investigated the impact of Drug-Drug Interactions (DDIs) on virologic control among HIV-positive pregnant women initiating antiretroviral therapy while identifying drivers for Traditional Medicine (TM) use and exploring the nature and extent of TM-related DDIs.
Methods: Employing a three-pronged approach, we examined DDIs arising from comedication, including TM, in ART. The DolPHIN-2 trial (NCT03249181) randomized 268 HIV-positive pregnant women in Uganda and South Africa to dolutegravir (DTG)-based (135) or efavirenz-based (133) regimens while systematically recording comedications and screening for DDIs.