Publications by authors named "M Nazim"

This study aims to explore the perspectives of medical students on the newly introduced Surgical Sub-internship (SI) rotation in year 5 Surgical Clerkship. This cross-sectional study was conducted at The Aga Khan University Hospital, Karachi, Pakistan from September 2022 to September 2023. A self-designed 5-point Likert scale-based evaluation form was created to explore students' perspectives regarding their one-week Surgical SI rotation.

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Post-transcriptional mechanisms, such as alternative splicing and polyadenylation, are recognized as critical regulatory processes that increase transcriptomic and proteomic diversity. The advent of next-generation sequencing and whole-genome analyses has revealed that numerous transcription and epigenetic regulators, including transcription factors and histone-modifying enzymes, undergo alternative splicing, most notably in the nervous system. Given the complexity of regulatory processes in the brain, it is conceivable that many of these splice variants control different aspects of neuronal development.

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The Industrial Internet of Things (IIoT) revolutionizes both industrial and residential operations by integrating AI (artificial intelligence)-driven analytics with real-time monitoring, optimizing energy usage, and significantly enhancing energy efficiency. This study proposes a secure IIoT framework that simultaneously predicts both active and reactive loads while also incorporating anomaly detection. The system is optimized for real-time deployment on an edge server, such as a single-board computer (SBC), as well as on a cloud or centralized server.

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  • Poor seedling germination leads to financial losses for farmers, creating a need for sustainable agricultural methods, notably through the use of nanotechnology, such as zinc oxide nanoparticles (ZnO NPs), to improve seed germination under stress.* -
  • The study focused on the effects of synthesized zinc oxide nanoparticles (S-ZnO NPs) on okra seeds, where 20 ppm concentration for 18 hours significantly improved germination rates, shoot and root lengths, and various weight measurements.* -
  • Additionally, the research found increases in chlorophyll content and antioxidant activity in the desi variety of okra, indicating the potential of S-ZnO NPs to reduce oxidative stress and enhance growth under optimal conditions.*
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  • - The process of turning embryonic stem cells into neurons involves complex regulation of several molecular processes, especially splicing, which is still not fully understood.
  • - Researchers discovered that the protein PTBP1 inhibits the splicing of DPF2, a key component of chromatin remodeling complexes, leading to the production of two different DPF2 isoforms (DPF2-S and DPF2-L) that influence cell behavior during development.
  • - The study shows that the DPF2-S isoform is linked to pluripotency factors in stem cells, while DPF2-L associates with different transcription factors in neuronal progenitors, suggesting that alternative splicing plays a significant role in organizing chromatin and gene expression during neuronal differentiation.
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