A DFT study of monolayer magnesium carbide (MgC) as a potential anode for (Li, Na, K) alkali metal-ion batteries.

Magnesium carbide (MgC) is the latest two-dimensional monolayer material with semiconductor properties containing 0.25 eV band gap. Upon adsorption of the Li/Na/K the semiconducting behavior of material changes to metallic.

Latitudinal clines in the phenology of floral display associated with adaptive evolution during a biological invasion.

Premise: Flowering phenology strongly influences reproductive success in plants. Days to first flower is easy to quantify and widely used to characterize phenology, but reproductive fitness depends on the full schedule of flower production over time. We investigated flowering schedules in relation to the onset and duration of flowering and tested for latitudinal clines in schedule shape associated with rapid evolution and range expansion of an invasive plant.

A one-week reduced-carbohydrate diet to mitigate iatrogenic peripheral hyperinsulinemia does not improve insulin sensitivity or endothelial function in a randomized, crossover trial in patients with type 1 diabetes.

Background: Iatrogenic peripheral hyperinsulinemia, resulting from peripheral insulin administration in type 1 diabetes, may increase insulin resistance and impair endothelial function. We hypothesized that lowering iatrogenic peripheral hyperinsulinemia via a one-week, reduced-carbohydrate diet (RCD) would improve insulin sensitivity and endothelial function compared with an isocaloric standard carbohydrate diet (SCD).

Methods: In this randomized, single-blinded, crossover trial, we studied 12 adults with type 1 diabetes.

Targeting the IL-17A pathway for therapy in early-stage tendinopathy.

Objectives: Tendinopathy is a frequent clinical problem and represents an extraordinary health economic and socioeconomic burden with high unmet medical needs. Recent clinical evidence suggests blockade of interleukin 17A (IL-17A) for tendinopathy therapy. The present preclinical study elucidates the biological mechanisms of IL-17A pathway stimulation and blockade in tendinopathy.

AMPK signaling is dysregulated in human tendinopathy and loss of AMPKα1 leads to cell, matrix and mechanical dysfunction in mouse Achilles tendon.

Tendinopathy is a tendon disorder that is caused by the failure to self-repair and has many pathological characteristics such as disorganized ECM and decreased cell viability. We have identified a possible target to combat these changes, AMPK, an energy stress sensor that was shown to maintain intracellular homeostasis. Through bulk RNA-sequencing of healthy and tendinopathic tendons from humans we have identified a novel finding of downregulation of AMPK signaling in the tendinopathic samples which suggests AMPK plays a role in tendon homeostasis.