Publications by authors named "M Nathan"
Thymic mimetic cells are molecular hybrids between medullary-thymic-epithelial cells (mTECs) and diverse peripheral cell types. They are involved in eliminating autoreactive T cells and can perform supplementary functions reflective of their peripheral-cell counterparts. Current knowledge about mimetic cells derives largely from mouse models.
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- Postoperative atrioventricular block requiring pacemaker (AVB/PM) affects 14% to 25% of patients undergoing complex biventricular repair for congenital heart disease, especially those with heterotaxy syndrome.
- This study explored the safety and effectiveness of intraoperative His bundle (HB) mapping to reduce the incidence of AVB/PM during these procedures.
- Results showed that mapping significantly lowered AVB/PM rates in certain groups, while also highlighting the need for ongoing advancements in mapping technology for those still at risk.
Background: Postoperative bleeding is associated with significant resource use and is an important contributor to other major adverse events in pediatric patients undergoing complex cardiac surgical procedures. Thromboelastography (TEG; TEG 6S, Haemonetics) can guide perioperative blood product transfusions to reduce the risk of postoperative bleeding. This study validated the use of a previously developed TEG 6S maximum amplitude (TEG-MA)-based platelet transfusion calculator used during cardiac surgical procedures to minimize the risk of postoperative bleeding.
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