Publications by authors named "M Narusawa"
In this study, we investigated the sleep-wake rhythm of nursery school children with the aim of supporting their health and mental/physical development. We analyzed 4881 children from infancy to 6 years of age, using 2 week sleep tables recorded by their guardians. The tables contained night bedtimes, wake times, nighttime/daytime sleep duration, and the differences in these between weekdays and weekends.
View Article and Find Full Text PDFProteus syndrome (PS) is characterized by the progressive, segmental, or patchy overgrowth of the skin, and other tissues. This is the first case report of recurrent severe insulin-independent hypoglycemia in an infant with PS. Somatic p.
View Article and Find Full Text PDFAmong cancer immunotherapies, granulocyte-macrophage colony-stimulating factor (GM-CSF) gene-transduced tumor cell vaccine (GVAX) therapies appear promising and have been shown to be safe and effective in multiple clinical trials. However, the antitumor efficacies of GVAX therapy alone are in some cases limited. Here we showed that GVAX therapy targeting cancer stem cells (CSCs) substantially suppressed tumor development in syngeneic immunocompetent mice recapitulating normal immune systems.
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- Erythropoiesis refers to the development and maturation of red blood cells, and understanding this process can help identify diseases linked to abnormal red blood cell production.
- In this study, researchers focused on genes that promote erythroid cell growth, finding that cells engineered to express RPL11 or RDH11 could grow without erythropoietin, displaying longer survival and altered hemoglobin types.
- Analysis showed that RPL11 led to faster cell proliferation compared to RDH11, with both proteins activating the STAT5 signaling pathway and increasing the expression of proteins related to cell cycle regulation and survival.
Article Synopsis
- Vaccination with GVAX, which uses irradiated tumor cells modified to produce GM-CSF, shows potential for inducing antitumor immunity but currently has limited effectiveness.
- * Researchers discovered that activating plasmacytoid dendritic cells (pDCs) in tumor-draining lymph nodes increases type I interferon gene expression, which is crucial for effective antitumor responses.
- * The combination of GVAX therapy with imiquimod enhances pDC activation and reduces regulatory T cells, resulting in a stronger immune response against tumors in mouse models.