Publications by authors named "M Naomi Horiba"

Background: Integrase strand transfer inhibitors (INSTIs) are recommended as first-line ART for people living with HIV (PLWH) in most guidelines. The INSTI-resistance-associated mutation E157Q, a highly prevalent (2%-5%) polymorphism of the HIV-1 (human immunodeficiency virus type 1) integrase gene, has limited data on optimal first-line ART regimens. We assessed the virological outcomes of various first-line ART regimens in PLWH with E157Q in real-world settings.

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  • A 59-year-old female with a long-standing history of Parkinson's disease developed rapidly destructive coxarthrosis and faced challenges with total hip arthroplasty (THA) due to her condition and its treatment side effects.
  • She was switched to levodopa-carbidopa intestinal gel (LCIG) therapy, which significantly improved her symptoms, allowing her to undergo THA using a dual mobility cup two months later.
  • One year post-surgery, her functional outcomes, including walking ability and motor scores, improved without recurrence of symptoms, indicating the potential benefits of this approach for similar patients.
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On January 19, 2023, the FDA granted accelerated approval to tucatinib in combination with trastuzumab for the treatment of patients with unresectable or metastatic RAS wild-type, HER2-positive colorectal cancer who have received prior treatment with fluoropyrimidine, oxaliplatin, and irinotecan. Approval was based on the pooled analysis of patients receiving tucatinib in combination with trastuzumab in MOUNTAINEER (NCT03043313), an open-label, multicenter trial. The primary endpoint was overall response rate (ORR) by RECIST 1.

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Objective: Gait disturbance lowers activities of daily living in patients with Parkinson's disease (PD) and related disorders. However, the effectiveness of pharmacological, surgical and rehabilitative treatments is limited. We recently developed a novel neuromodulation approach using gait-combined closed-loop transcranial electrical stimulation (tES) for healthy volunteers and patients who are post-stroke, and achieved significant entrainment of gait rhythm and an increase in gait speed.

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  • - Late HIV diagnosis in Japan is a significant issue, particularly among young men who have sex with men (MSM) in urban areas, and the study aimed to understand various factors contributing to this problem, including demographics and clinical aspects.
  • - The research analyzed anonymized data from nearly 10,000 newly diagnosed HIV cases from 2003 to 2019, revealing that 71.2% of participants experienced late diagnosis, with a median CD4 count of 221 cells/μl at diagnosis.
  • - Key factors linked to late HIV diagnosis included older age, heterosexual transmission, living outside of Tokyo, co-infection with hepatitis C, and not being part of a genetic cluster, while a specific HIV subtype (CRF
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