Publications by authors named "M Nandy"
Natural product synthesis has been the prime focus for the development of new chemical transformations and the drug discovery. The dimeric and oligomeric hexahydropyrrolo[2,3-b]indole alkaloids represent a architecturally intriguing class of cyclotryptamine alkaloids. These alkaloids share contiguous stereogenic centers with vicinal all-carbon quaternary stereogenic centers.
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- - Hard ticks use a protein-rich saliva to attach securely to their hosts, forming a solid cement cone, but the process behind this transformation is not yet understood.
- - This study investigates a glycine-rich protein (GRP) in tick saliva, revealing that it can undergo liquid-liquid phase separation to form sticky biomolecular condensates in salty conditions.
- - The research identifies key interactions in GRP that drive this phase separation and suggests that understanding these mechanisms could lead to new tick control methods and innovative biomedical applications like tissue sealants.
(+)-Brevianamides A () and B () are distinguished by their unique bicyclo[2.2.2]diazaoctane structure and have captured the interest of synthetic chemists due to their fascinating array of biological activities.
View Article and Find Full Text PDFWe report the asymmetric total synthesis of dixiamycin C (1) through the shrewd alliance of the naturally occurring monomer xiamycin A methyl ester (5) and its bromo derivative (31) following a late-stage Buchwald-Macmillan's C-N bond formation via a photoredox electron transfer approach with a less reactive carbazole nitrogen. The key step in the synthesis of monomer xiamycin A methyl ester (5) involves Buchwald's Pd(II)-mediated aerobic dehydrogenative C-N bond formation, Beckmann rearrangement, and -acetylation of an electron-rich aromatic ring of an abietane core.
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