Publications by authors named "M Nakata"
Background Motor evoked potential (MEP) monitoring is a commonly employed method in neurosurgery to prevent postoperative motor dysfunction. However, it has low prediction accuracy for postoperative paralysis. This study aimed to develop a decision tree (DT) model for predicting postoperative motor function using MEP monitoring data.
View Article and Find Full Text PDFThe basic requirements for the development of radiopharmaceuticals for radionuclide therapy of tumors include marked tumor-specific accumulation and long-term intratumoral retention. We have previously reported an indium-111 (In)-labeled thermoresponsive polymer (polyoxazoline (POZ)) that is soluble at body temperature with rapid clearance from normal tissues but self-aggregates in the tumor upon tumor heating treatment. POZ accumulated in the tumor via self-aggregation under hyperthermic conditions and was retained after stopping heat exposure.
View Article and Find Full Text PDFPurpose: This study aimed to investigate the current practices in the diagnosis and surgical management of anorectal malformations (ARMs) in female patients in Japan, specifically focusing on anovestibular fistula (AVF), rectovaginal fistula (RVF), and persistent cloaca (PC).
Methods: An anonymous online survey was conducted with 61 institutional members of the Japanese Study Group for Anorectal Anomalies.
Results: Sixty-one institutions (100%) completed the survey.
Article Synopsis
- * Using mouse models, researchers found that renal injury activated the mineralocorticoid receptor (MR), which was linked to increased levels of HMGB1 and RAGE, and that blocking this pathway lessened kidney damage and inflammation.
- * Results indicate that HMGB1 is a key factor in the development of AKI and its progression to CKD by activating the Rac1/MR pathway, suggesting potential therapeutic targets for preventing kidney injury.
Article Synopsis
- Genome editing techniques, especially CRISPR/Cas9, still face challenges with gene knock-ins in silkworms, but recent research has identified effective methods for this.
- The study validated several CRISPR/Cas9-mediated knock-in methods, discovering that short single-stranded oligodeoxynucleotide (ssODN) methods were the most successful.
- Knock-in silkworm strains were created with specific genetic sequences, which opens new avenues for studying gene functions in insects and improving genome editing applications.