Publications by authors named "M Nakakita"
Characterizing prefrontal cortical activity during inhibition task in methamphetamine-associated psychosis versus schizophrenia: a multi-channel near-infrared spectroscopy study.
Addict Biol
March 2016
Article Synopsis
- Methamphetamine abuse often leads to serious psychological issues, including symptoms similar to schizophrenia, termed methamphetamine-associated psychosis (MAP), which presents a significant global health concern.
- A study was conducted comparing brain activity during cognitive tasks among patients with MAP, patients with schizophrenia, and healthy individuals, using a specialized imaging technique.
- Both MAP and schizophrenia patients showed reduced activation in certain brain areas, but only MAP patients exhibited unique impairments, indicating both shared and distinct brain dysfunctions linked to these conditions.
To investigate the importance of the cadmium (Cd) exposure condition in the evaluation of toxic effect on renal function and bone metabolism, six groups of Male Wistar rats were given Cd at respective daily doses of 2, 5, 10, 20, 30 and 60 mgCd/kg (as CdCl2) via a gastric tube for 6 consecutive days a week for 60 weeks. In the groups given a low Cd dose (2, 5 and 10 mgCd/kg), relatively more Cd accumulated in the kidney without liver damage than in the liver. In the high Cd dose groups (20, 30 and 60 mgCd/kg), on the other hand, more Cd accumulated in the liver than in the kidney.
View Article and Find Full Text PDFSimilar to the prostanoid-mediated inflammatory response in mammals, jasmonate-mediated wound response in plant leaves is inhibited by salicylic acid (SA) or acetylsalicylate (aspirin). In tobacco BY-2 cells, expression of the gene for ornithine decarboxylase (ODC) involved in putrescine synthesis is rapidly inducible by methyl jasmonate (MeJA). A nuclear gene for ODC isolated from tobacco, gNtODC-1, was an intron-less gene and MeJA induced the expression of a GUS fusion gene with the gNtODC-1 promoter in transformed tobacco cells.
View Article and Find Full Text PDFThe aim of the present study was to establish a useful animal model that simulates humans sensitive to inhaled particulate matter (PM). We have developed a new rat model of acute bronchiolitis (Br) by exposing animals to NiCl2 (Ni) aerosols for five days. Three days following the Ni exposure, the animals developed signs of tachypnea, mucous hypersecretion, and bronchiolar inflammation which seemed to progress quickly during the fourth to fifth day.
View Article and Find Full Text PDF