Orbital Septum Posterior to Medial Canthal Tendon Area.

Purpose: To examine the anatomy of the orbital septum posterior to the medial canthal tendon area.

Materials And Methods: We performed 3 anatomical dissections in the present study. The first one was a microscopic study in which exenterated specimens from 6 Japanese cadavers (age from 77 to 93 years at death) were cut inferno-horizontally, including the Müller muscle, medial rectus pulley, and lateral rectus pulley, and stained with Masson's trichrome.

The impact of a short-term high-fat diet on coagulation function in a mouse model and its role in exacerbating concanavalin A-induced liver injury.

Background: Recently, the number of patients with metabolic dysfunction-associated steatotic liver disease (MASLD) and its more advanced condition, metabolic dysfunction-associated steatohepatitis (MASH), has been increasing. These patients are at a higher risk of cardiovascular events and thromboembolism. However, the direct impact of high-fat diet (HFD), a cause of MASLD, on liver coagulation function is not well understood.

Role of versican in extracellular matrix formation: analysis in 3D culture.

Three-dimensional cell culture creates an environment that allows cells to grow and interact with the surrounding extracellular framework. Versican plays a pivotal role in forming the provisional matrix, but it is still unclear how this proteoglycan affects the formation of the extracellular matrix. Here, we established a three-dimensional culture system using fibrin gel, which enables a long-term culture up to a month.

Brain region-specific neural activation by low-dose opioid promotes social behavior.

The opioid system plays crucial roles in modulating social behaviors in both humans and animals. However, the pharmacological profiles of opioids regarding social behavior and their therapeutic potential remain unclear. Multiple pharmacological, behavioral, and immunohistological c-Fos mapping approaches were used to characterize the effects of μ-opioid receptor agonists on social behavior and investigate the mechanisms in naive mice and autism spectrum disorder-like (ASD-like) mouse models, such as prenatally valproic acid-treated mice and Fmr1-KO mice.

Dual Porphyrin-Loaded Scintillating Nanoparticles Enhanced Photodynamic Therapy in Hypoxic Cancer Cells under X-ray Irradiation.

Tumor hypoxia represents a major challenge to achieving successful therapy outcomes with photodynamic therapy (PDT). We hypothesized that systemic loading of dual porphyrins, protoporphyrin IX (PPIX) as a photosensitizer (PS) and hemin (Fe-PPIX) as an oxygen generator, onto Eu-doped NaYF scintillator (Sc), collectively terms as Eu-PPIX@Hemin, could enhance the activity of X-ray mediated PDT. Catalase-like property of hemin in the presence of HO facilitated the production of oxygen molecules (O) in hypoxic cancer cells.