Publications by authors named "M Nagamine"
Mas-related G protein-coupled receptor b2 (Mrgprb2) binding to its cationic endogenous and exogenous ligands induces mast cell degranulation and promotes inflammation in mice. However, the physiological roles of its human homologue MRGPRX2 remain unclear. Here we aimed to elucidate the mechanisms by which MRGPRX2 regulates vascular permeability, and generated MRGPRX2 knock-in (MRGPRX2-KI) and Mrgprb2 knockout (Mrgprb2-KO) mice.
View Article and Find Full Text PDFBackground: End stage renal disease (ESRD) requiring hemodialysis (HD) increases mortality among patients with intracerebral hemorrhage (ICH). The aim of this study is to investigate the clinical characteristics and outcome of ICH patients with ESRD on HD versus propensity-score matched controls.
Methods: This is a single center retrospective study.
Objectives: Physical inactivity and sedentary time can worsen mental health; however, their relationship remains elusive, and related evidence among workers with overseas assignments is limited. Therefore, this study aimed to investigate the relationship between changes in physical activity and sedentary time and explored the subsequent risk of psychological distress among Japan Self-Defense Forces personnel.
Methods: This prospective study enrolled male Japan Self-Defense Forces personnel dispatched to the Republic of Djibouti from May 2018 to June 2019.
Self-compassion as a protective factor against post-traumatic stress symptoms induced by adverse childhood experiences: A cross-sectional study among Japan air self-defense force new recruits.
J Psychiatr Res
December 2024
Article Synopsis
- Adverse childhood experiences (ACEs) are linked to long-term mental health issues like PTSD, and are notably more common in military personnel who must preserve mental health for their duties.
- A study with 752 recruits from the Japan Air Self-Defense Force found that self-compassion, which involves treating oneself kindly, significantly reduces PTSD symptoms and is negatively impacted by ACEs.
- The research indicated that self-compassion only partially mediates the relationship between ACEs and PTSD symptoms, suggesting the need for further studies to develop educational programs aimed at increasing self-compassion in individuals with ACEs to help lessen PTSD symptoms.
Article Synopsis
- * The research analyzed samples from three canine OMM cell lines and human melanoma cell lines, identifying a total of 500 mutated genes in dogs, including notable ones like EP300 and NOTCH1, with 82 mutations shared between dogs and humans.
- * These findings offer important insights for understanding the genetic landscape of OMMs and could lead to the development of new treatment options for both canine and human patients in the future.