Mechanochemical Functionalization of Oxidized Carbon Black with PLA.

The functionalization of carbon black (CB) represents a promising strategy to enhance its compatibility with polymers while addressing sustainability concerns. In this study, a solvent-free mechanochemical approach (ball milling) is proposed for the functionalization of oxidized carbon black (oCB) with post-consumed polylactic acid (PLA), overcoming the environmental drawbacks of conventional methods that mostly rely on toxic solvents and catalysts. The functionalized carbon black (f-CB) was characterized by Fourier transform infrared spectroscopy (FTIR), elemental analysis (EA), and thermogravimetric analysis (TGA) to confirm the successful modification.

Epigenetic age acceleration in hematopoietic stem cell transplantation.

Not available.

Synergic activity of FGFR2 and MEK inhibitors in the treatment of FGFR2-amplified cancers of unknown primary.

Patients with cancer of unknown primary (CUP) carry the double burden of an aggressive disease and reduced access to therapies. Experimental models are pivotal for CUP biology investigation and drug testing. We derived two CUP cell lines (CUP#55 and #96) and corresponding patient-derived xenografts (PDXs), from ascites tumor cells.

CAR+ extracellular vesicles predict ICANS in patients with B cell lymphomas treated with CD19-directed CAR T cells.

BACKGROUNDPredicting immune effector cell-associated neurotoxicity syndrome (ICANS) in patients infused with CAR T cells is still a conundrum. This complication, thought to be consequent to CAR T cell activation, arises a few days after infusion, when circulating CAR T cells are scarce and specific CAR T cell-derived biomarkers are lacking.METHODSCAR+ extracellular vesicle (CAR+EV) release was assessed in human CD19.