Next-generation sequencing of and in breast cancer patients and control subjects.

Breast cancer is currently the most common type of cancer in females. The majority of the hereditary forms of breast cancer are caused by mutations in the and genes, whose main function is the DNA repair of double-strand breaks. Genetic testing of females with a family history of breast cancer is recommended to determine their hereditary predisposition for this type of cancer.

[Primary ectopic intraosseous meningioma associated with multiple meningioma in a patient with central neurofibromatosis].

We present a case of multiple meningiomas (MM) as initial manifestation of central neurofibromatosis (NF2). A 19 y. o.

Familial breast cancer. Part III: Genome instability and cancer risk.

Purpose: The purpose of part III of this study was to direct our efforts towards more detailed genetic studies, which can be used in genetic counselling of patients with breast cancer and their relatives.

Patients And Methods: We investigated 52 patients, 25 with chromosomal fragility and 17 with spontaneous chromosomal aberrations, all with familial breast cancer (study group). The control group consisted of 10 healthy women without a history of proliferative diseases or breast cancer in their families.

Familial breast cancer. Part II: Relationships with histology, staging, steroid receptors and serum tumor markers.

Purpose: To identify differences in clinical characteristics, histological features, hormone receptor status, and tumor marker expression between patients with sporadic and familial breast cancer.

Patients And Methods: As in the previous Part I of this study, two groups of women with breast cancer were compared. The first group (group I) included 504 patients with a family history of breast cancer.

Familial breast cancer. Part IV: survival of familial breast cancer in Bulgarian patients.

Purpose: The aim of part IV of this study was to register and compare the survival rates of sporadic and familial breast cancer, and to estimate the prognostic value of familial predisposition of the disease as a risk factor.

Patients And Methods: We investigated retrospectively 504 patients belonging to families with accumulation of the disease (study group, group I) and 300 patients with the sporadic form of breast cancer (control group, group II). All patients were diagnosed, treated, and followed-up at the Clinic of Thoracic Surgery, National Oncological Centre.