Caliciviruses are a diverse group of non-enveloped, positive-sense RNA viruses with a wide range of hosts and transmission routes. Norovirus is the most well-known member of the ; the acute gastroenteritis caused by human norovirus (HuNoV), for example, frequently results in closures of hospital wards and schools during the winter months. One area of calicivirus biology that has gained increasing attention over the past decade is the conformational flexibility exhibited by the protruding (P) domains of the major capsid protein VP1.
View Article and Find Full Text PDFNeuropsychiatric disorders are a public health concern, in which diagnosis and prognosis may be based on clinical symptoms that might often diverge across individuals. Schizophrenia is a major neuropsychiatric disorder, which may affect millions worldwide. However, the biochemical alterations of this disorder have not been comprehensively distinguished.
View Article and Find Full Text PDFThis study aimed to investigate the cause of susceptibility underestimation in body quantitative susceptibility mapping (QSM) and propose a water/fat separate reconstruction to address this issue. A numerical simulation was conducted using conventional QSM with/without body masking. The conventional method with body masking underestimated the susceptibility across all regions, whereas the method without body masking estimated an equivalent value to the ground truth.
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