Large clones of Clonal Hematopoiesis affect outcome in Mantle Cell Lymphoma: Results from The FIL MCL0208 Clinical Trial.

Although recent evidence suggests that myeloid clonal hematopoiesis (M-CH) may influence lymphoma clinical outcome, its impact in mantle cell lymphoma (MCL) remains unclear. Here, we report a comprehensive NGS-based analysis of the M-CH mutational landscape at baseline and follow-up in patients enrolled in the Fondazione Italiana Linfomi (FIL) MCL0208 phase 3 trial (NCT02354313), evaluating lenalidomide maintenance versus observation after chemoimmunotherapy and autologous stem cell transplantation (ASCT) in untreated young MCL patients. Overall, 254/300 (85%) enrolled patients (median age 57 years [32-66]) had a baseline sample available for CH analysis.

Safety assessment of the process NGR LSP used to recycle post-consumer PET into food contact materials.

The EFSA Panel on Food Contact Materials (FCM) assessed the safety of the recycling process NGR LSP (EU register number RECYC328). The input is hot washed and dried poly(ethylene terephthalate) (PET) flakes mainly originating from collected post-consumer PET containers, with no more than 5% PET from non-food consumer applications. The flakes are dried (step 2), melted in an extruder (step 3) and decontaminated during a melt-state polycondensation step under high temperature and vacuum (step 4).

Increased attention towards progress information near a goal state.

A growing body of evidence across psychology suggests that (cognitive) effort exertion increases in proximity to a goal state. For instance, previous work has shown that participants respond more quickly, but not less accurately, when they near a goal-as indicated by a filling progress bar. Yet it remains unclear when over the course of a cognitively demanding task do people monitor progress information: Do they continuously monitor their goal progress over the course of a task, or attend more frequently to it as they near their goal? To answer this question, we used eye-tracking to examine trial-by-trial changes in progress monitoring as participants completed blocks of an attentionally demanding oddball task.

Nutritional Deficiencies Before and After Metabolic and Bariatric Surgery in Patients Above 50.0 kg/m: A Single Center Study.

Purpose: Metabolic and bariatric surgery (MBS) is an effective treatment for patients with body mass index (BMI) above 50.0 kg/m but nutritional deficiencies (ND) may arise. This study aimed to assess if patients with BMI above 50.

EVALUATION OF IDIOPATHIC SCOLIOSIS IN SUBTYPES OF PECTUS EXCAVATUM AND CARINATUM.

Objective: Evaluation of epidemiological data on Idiopathic Scoliosis in patients with different pectus subtypes.

Methods: A medical record analysis of 418 patients with pectus, associated with idiopathic scoliosis above 10°, with research on: subtypes of pectus (Lateral Pectus Carinatum, Inferior Pectus Carinatum, Superior Pectus Carinatum, Broad Pectus Excavatum, and Localized Pectus Excavatum), and characteristics of the scoliotic curve (Cobb angle, laterality, and location).

Results: The mean age was 14.