Publications by authors named "M N Vissers"
We present a method of creating high-density superconducting flexible wiring on flexible thin silicon substrates. The flexible wiring, called , is created by depositing superconducting wiring on a silicon-on-insulator (SOI) wafer, selectively etching away the thicker silicon section layer, and bending the thinner silicon layer. We show measurements of superconducting transition temperature and critical current for Mo, Nb, and Al on SOI flex.
View Article and Find Full Text PDFSingle-photon detectors based on the superconducting transition-edge sensor are used in a number of visible to near-infrared applications, particularly for photon-number-resolving measurements in quantum information science. To be practical for large-scale spectroscopic imaging or photonic quantum computing applications, the size of visible to near-infrared transition-edge sensor arrays and their associated readouts must be increased from a few pixels to many thousands. In this manuscript, we introduce the kinetic inductance current sensor, a scalable readout technology that exploits the nonlinear kinetic inductance in a superconducting resonator to make sensitive current measurements.
View Article and Find Full Text PDFArticle Synopsis
- Glioblastoma, an aggressive brain cancer, is linked to low oxygen levels (hypoxia) and poor patient survival, driven by the activity of a transcription factor called hypoxia-inducible factor (HIF).
- HIF-hydroxylases, which require vitamin C (ascorbate) to function, are crucial for regulating HIF and the hypoxic pathway; a decrease in these enzymes leads to increased cancer progression.
- The study showed that glioblastoma cells use the sodium-dependent vitamin C transporter-2 (SVCT2) to accumulate ascorbate, and knocking out this transporter significantly reduced ascorbate levels and limited its ability to suppress the hypoxic pathway, suggesting that boosting ascorbate levels could
Investigational therapeutics that target toxic species of α-synuclein (αSyn) aim to slow down or halt disease progression in patients with Parkinson's disease (PD). Here this 44-week, randomized, placebo-controlled, double-blind, single-center phase 1 study investigated safety, tolerability and immunogenicity of UB-312, an active immunotherapeutic targeting pathological αSyn, in patients with PD. The primary outcome measures were adverse event frequency and change in anti-αSyn antibody titers in blood and cerebrospinal fluid (CSF).
View Article and Find Full Text PDFBackground: Young children and older adults are susceptible for invasive pneumococcal disease (IPD) caused by Streptococcus pneumoniae. Pneumococcal protein-specific antibodies play a protective role against IPD; however, not much is known about the pace of acquisition, maturation, and maintenance of these antibodies throughout life.
Methods: Immunoglobulin G (IgG) and IgA levels, avidity, and/or specificity to the pneumococcal proteome in serum and saliva from healthy young children, adults, and older adults, with known carriage status, were measured by enzyme-linked immunosorbent assay (ELISA) and 2-dimensional western blotting against ΔcpsTIGR4.