Basic Science and Pathogenesis.

Background: Aging, tau pathology, and chronic inflammation in the brain play crucial roles in neuroinflammation, synaptic loss, neurodegeneration, and cognitive decline in tauopathies, such as Alzheimer's disease. However, the molecular mechanisms that trigger aberrant chronic inflammatory signaling in tauopathies are poorly understood.

Method: We utilized brain tissues from tauopathy patients and the tauopathy mouse models.

Validated LC-MS/MS Method for the Determination of Paxalisib on Mouse Dried Blood Spots: An Application to Pharmacokinetic Study in Mice.

Paxalisib is a dual PI3K/mTOR inhibitor, being used in advanced cancer treatment. In this research, we report a validated LC-MS/MS method for quantifying paxalisib from mouse dried blood spot (DBS). We validated the method in-line with the FDA guidelines.

Machine learning-based technique for gain prediction of mm-wave miniaturized 5G MIMO slotted antenna array with high isolation characteristics.

This study presents the design and analysis of a compact 28 GHz MIMO antenna for 5G wireless networks, incorporating simulations, measurements, and machine learning (ML) techniques to optimize its performance. With dimensions of 3.19 λ₀ × 3.

High-Density and Well-Aligned Hierarchical Structures of Colloids Assembled under Orthogonal Magnetic and Electric Fields.

Colloids can be used either as model systems for directed assembly or as the necessary building blocks for making functional materials. Previous work primarily focused on assembling colloids under a single external field, where controlling particle-particle interactions is limited. This work presents results under a combination of electric and magnetic fields.

Contagion comeback: unravelling the measles outbreak across the USA.

Measles, a highly contagious respiratory illness caused by the measles virus (MeV), poses significant global and national public health challenges despite advancements in vaccination efforts. Though measles was declared eliminated in the United States in 2000, recent years have seen a resurgence of cases, particularly in under-vaccinated communities. This resurgence is compounded by factors such as vaccine hesitancy, the impact of the COVID-19 pandemic on immunization rates, and international travel introducing new cases from endemic regions.