Publications by authors named "M N Tsolia"
Aim: Irisin, a newly discovered adipomyokine, has pleiotropic effects in metabolic and energy homeostasis, insulin resistance (IR), and browning of white adipose tissue. The aim of this study was to evaluate irisin levels in children with obesity and also to elucidate possible relationships between irisin with anthropometric obesity indices, parameters of metabolic syndrome (MetS), and intima media thickness (IMT).
Methods: A total of 77 prepubertal children, 4-12 years old, were enrolled in this study, including 44 children with obesity (BMI ≥ 95th percentile) and 33 normal weight controls of matched age and gender.
Article Synopsis
- The study assessed the levels of antibodies against diphtheria, pertussis, and tetanus in pregnant women at two maternity hospitals in Athens from 2017 to 2019, revealing low seropositivity rates, particularly for diphtheria and pertussis.
- The analysis involved 253 blood samples, showing 57.7% seropositivity for diphtheria, 12.5% for pertussis, and 92.7% for tetanus, with better outcomes seen in older and more educated women.
- Less than 2% of participants reported receiving the recommended Tdap vaccination during pregnancy, indicating a gap in vaccination adherence and suggesting the need for national awareness campaigns to
Article Synopsis
- Diagnosing pediatric tuberculosis (TB) is complicated, but changes in host gene expression in blood can help identify biomarkers and improve understanding of the immune response in children with TB.* -
- The study involved stimulating blood samples from 102 children with confirmed TB, TB infection, pneumonia, and healthy controls, and analyzing the gene expression differences using microarrays.* -
- Researchers identified specific gene signatures that effectively distinguish TB from pneumonia, with high accuracy (AUC of 100% for one gene and 91.7% for a combination of two genes), paving the way for new diagnostic tests aligned with WHO standards.*
Article Synopsis
- The study assesses the effectiveness of white blood cell count (WBC) in predicting serious bacterial infections (SBI) in children compared to C reactive protein (CRP) and absolute neutrophil count (ANC).
- After analyzing data from over 17,000 febrile children across multiple European emergency departments, WBC showed poor predictive value with a sensitivity of 56% and specificity of 74% for WBC >15.
- The findings suggest that CRP is a better marker for identifying SBI in children, and WBC should only be used for specific cases rather than as a routine diagnostic tool.