Publications by authors named "M N Tourret"
Introduction: Transhiatal esophagectomy (THE) is used for specific gastroesophageal junction adenocarcinomas. THE is a high-risk surgical procedure. We aimed to assess the impact of postoperative sepsis (sepsis or septic shock) on the 1-year mortality after THE and to determine the risk factors associated with these outcomes.
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- - Chicory is being researched as a functional food, and this study examines how gastrointestinal digestion affects its composition and bioactive properties by creating an aqueous decoction from chicory flour.
- - The study utilized a metabolomic approach to observe how digestion changes specific bioactive molecules across different stages (oral, gastric, and intestinal) and evaluated antioxidant, anti-inflammatory, and hormone regulation effects before and after digestion.
- - Results showed that digestion alters chlorogenic acid and sesquiterpene lactones, enhancing chicory's antioxidant and anti-inflammatory effects, with a notable increase in reactive oxygen species (ROS) scavenging capacity and metabolite activity post-digestion.
Background: Radical cystectomy (RC) is a major surgery associated with a high morbidity rate. Perioperative fluid management according to enhanced recovery after surgery (ERAS) protocols aims to maintain patients in an optimal euvolemic state while exposing them to acute kidney injury (AKI) in the event of hypovolemia. Postoperative AKI is associated with severe morbidity and mortality.
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- The study investigates the use of mucosal-associated invariant T (MAIT) cells to prevent or reduce graft-versus-host disease (GVHD), a significant complication after stem cell transplants.
- Researchers found that MAIT cells can inhibit the activation of alloreactive T cells in vitro and effectively delay or lessen the severity of GVHD in a preclinical mouse model when given shortly after PBMC infusion.
- The immunosuppressive effects of MAIT cells were linked to reduced levels of inflammatory cytokines like IFN-γ and TNF-α, while increasing anti-inflammatory IL-10, suggesting MAIT cells could be a promising treatment for GVHD and related conditions in future
Background: Biliary sepsis is common in patients with digestive cancer. Recommendations call for antibiotic de-escalation (ADE) as a strategy for antibiotic treatment of sepsis or septic shock. The aim of this study was to identify factors influencing 90-day mortality and to evaluate the impact of ADE.
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