Publications by authors named "M N Sotto"
Article Synopsis
- Folliculitis decalvans (FD) is a chronic hair loss condition with an unclear cause, but recent research indicates a link to IL-17 secretion by mast cells.
- A study found higher levels of IL-17 and mast cells in affected areas of the scalp compared to unaffected areas, suggesting an inflammatory response.
- The results indicate that targeting IL-17 and mast cells may help manage the chronic inflammation associated with severe cases of FD.
Article Synopsis
- Dengue virus (DENV) is a serious global health issue that can cause severe disease affecting various organs, including the kidneys, where immune responses and cell death mechanisms like pyroptosis and necroptosis play key roles.
- The study focused on analyzing kidney tissue from victims of DENV to identify specific markers related to different cell death pathways (necroptosis, pyroptosis, and autophagy) and to understand tissue changes resulting from the infection.
- Results showed significant kidney damage, including glomerular congestion and acute injury, with varying expressions of markers for autophagy, pyroptosis, and necroptosis, indicating an intricate
Introduction: Pathogenesis of cutaneous leishmaniases involves parasite growth, persistent inflammation, and likely participation of lipoproteins (LP). The cholesteryl ester transfer protein (CETP), involved in LP remodeling, has been shown to participate in the inflammatory response and the evolution of infectious conditions.
Methods: We evaluated the impact of the presence of CETP on infection by in an experimental model of cutaneous leishmaniasis using C57BL6/J mice transgenic for human CETP (CETP), having as control their littermates that do not express the protein, wild-type (WT) mice.
Atopic dermatitis (AD) is an inflammatory skin disease with intense pruritus, and chronic skin colonization by Staphylococcus aureus. To understand the inflammatory status in AD, we investigated the inflammasome complex, that activates ASC (Apoptosis-associated speck-like protein containing a CARD), caspase-1 and GSDMD (gasdermin-D), and production of IL-1β and IL-18. We aimed to evaluate the expression of the inflammasome pathway in the skin of adults with AD.
View Article and Find Full Text PDF