Publications by authors named "M N Shehu"
Objectives: Greater vulnerability of Black vs. White individuals to cardiovascular disease (CVD) and chronic kidney disease (CKD) is well charted in the United States, but studies involving sub-Saharan blacks are scarce.
Methods: Baseline data (2021-2024) were collected in 168 sub-Saharan Blacks and 93 European Whites in an ongoing clinical trial (NCT04299529), using standardized patient selection criteria.
Introduction/background: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia. The AF Atrial Fibrillation Registry, which commenced in June 2023, was designed to provide clinical epidemiological data on patients with AF in the country.
Objective(s): The objective is to describe the rationale, design, and early findings from the registry.
Article Synopsis
- Chronic heart failure (CHF) presents distinct gender-specific factors that impact patient care, yet women are underrepresented in related studies, highlighting a need for more focused research.
- This study examines 1,290 CHF patients to analyze gender differences in causes, comorbidities, treatment, and one-year mortality rates.
- Findings reveal that men, who made up 55.8% of the study group, generally had worse health outcomes, prevalent comorbidities, and higher mortality rates compared to women, suggesting significant gender disparities in CHF profiles.
Thymoquinone ameliorate oxidative stress, GABAergic neuronal depletion and memory impairment through Nrf2/ARE signaling pathway in the dentate gyrus following cypermethrin administration.
BMC Neurosci
September 2024
Article Synopsis
- - The study investigates how thymoquinone can protect the brain from damage caused by the insecticide cypermethrin, focusing on its effects within the dentate gyrus region responsible for memory and motor functions.
- - Forty adult male rats were divided into five groups, receiving various treatments over 14 days, including combinations of cypermethrin and thymoquinone, followed by tests to assess memory and brain health.
- - Results indicate that thymoquinone improves memory performance and supports brain cell integrity while reducing neurotoxic effects of cypermethrin, suggesting its potential as a treatment for pesticide-related neurotoxicity.
Honey and levodopa comparably preserved substantia nigra pars compacta neurons through the modulation of nuclear factor erythroid 2-related factor 2 signaling pathway in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson's disease model.
Anat Cell Biol
September 2024
Parkinson's disease (PD) affects about 8.5 million individuals worldwide. Oxidative and inflammatory cascades are implicated in the neurological sequels, that are mostly unresolved in PD treatments.
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