Publications by authors named "M N Rivas"
Midline venous catheter: New insights for its use in hospitalized patients with diabetes.
Diabetes Res Clin Pract
January 2025
In a prospective study we found that in hospitalized patients with diabetes the use of mid line venous catheter (MVC) resulted in a significantly lower rate of vascular complications than short cannulas. However, a special attention should be paid to catheter obstruction when MCV is used.
View Article and Find Full Text PDFReplacement of the essential catalytic aspartate with serine leads to an active form of copper-containing nitrite reductase from the denitrifier Sinorhizobium meliloti 2011.
Lorieth A Guevara Cuasapud Pablo J González Félix M Ferroni Andrea B Duré Sergio D Dalosto Maria G Rivas
Biochim Biophys Acta Proteins Proteom
December 2024
Article Synopsis
- The study details the characterization of a mutated variant of copper-containing nitrite reductase (SmNirK) from S. meliloti, where the catalytic aspartate (Asp) is replaced with serine (Ser) via site-directed mutagenesis.
- The D134S variant retains the homotrimer structure and similar T1 electron transfer center to the wild-type, but shows altered electronic properties in the T2 active site, impacting its enzymatic efficiency and pH dependence.
- EPR studies reveal significant changes in the T2 properties due to the mutation, highlighting the role of T2 ligands in catalysis and suggesting a potential mechanism for electron transfer influenced by the Asp/Ser switch.
Study Design: Retrospective data analysis study.
Objectives: To assess gait recovery rates in subjects with motor incomplete spinal cord injury (SCI) at the start of rehabilitation and to report their gait performance.
Setting: Tertiary inpatient Rehabilitation Center in Argentina.