Publications by authors named "M N Plana Farras"
Article Synopsis
- The study investigated the links between saturated and unsaturated fatty acids and cardiovascular disease (CVD), focusing on conditions like coronary heart disease (CHD) and stroke in a large group of participants.
- Results showed that higher levels of saturated fatty acids were linked to increased CVD risks, with specific subtypes having varying effects on CHD and stroke.
- Conversely, higher concentrations of certain polyunsaturated fatty acids (both n-3 and n-6 types) were associated with lower risks of CHD and stroke, suggesting dietary fats play a significant role in cardiovascular health.
Article Synopsis
- Non-alcoholic fatty liver disease (NAFLD) and metabolic syndrome (MetS) are linked to higher overall and cause-specific mortality risks, particularly cancer and cardiovascular disease (CVD).
- A study involving 15,784 participants found that a higher Fatty Liver Index (FLI), indicating more severe liver fat accumulation, correlated with increased mortality rates, especially for CVD.
- Individuals with metabolic dysfunction-associated fatty liver disease (MAFLD) and metabolic syndrome show heightened mortality risks, suggesting the need for greater awareness and management of these conditions.
This study aims to determine the concentrations of tramadol in earwax (μg/g) and urine (μg/ml) samples taken from postoperative patients, to evaluate the sensitivity of earwax (cerumen) as an alternative analyte and compare it with the findings in urine samples. The results indicated that tramadol concentrations in earwax samples were averaged 45.08 μg/g (range: 13.
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- Accumulation of lipid-laden macrophages is vital in forming atherosclerotic plaques, and reduced ZEB1 levels in these cells lead to larger plaques and increased cardiovascular risk.
- Male mice lacking ZEB1 in myeloid cells show significant lipid build-up and metabolic issues, indicating that ZEB1 deficiency worsens atherosclerosis.
- Targeted delivery of ZEB1 using nanoparticles can reverse lipid accumulation and reduce plaque formation, suggesting that ZEB1 could be an important therapeutic target for atherosclerosis.
Background: Whether cancer risk associated with a higher body mass index (BMI), a surrogate measure of adiposity, differs among adults with and without cardiovascular diseases (CVD) and/or type 2 diabetes (T2D) is unclear. The primary aim of this study was to evaluate separate and joint associations of BMI and CVD/T2D with the risk of cancer.
Methods: This is an individual participant data meta-analysis of two prospective cohort studies, the UK Biobank (UKB) and the European Prospective Investigation into Cancer and nutrition (EPIC), with a total of 577,343 adults, free of cancer, T2D, and CVD at recruitment.