[Endothelial dysfunction and nonspecific immune reactions in development and progression of osteoarthrosis in women engaged into manual work].

The article considers mechanisms of development and progression of osteoarthrosis as an occupationally conditioned disease in women of manual work. Women working in physical overstrain conditions are under occupational risk with dysfunction of many body systems. The authors set a hypothesis on association of endothelial dysfunction markers dysbalance and structural remodelling of cartilage matrix as a proof of degenerative changes.

[Morphometric characteristics of microcirculatory bed of olfactory bulbs in the desympathized albino rat].

To detect the effect of postnatal chemical desympathization on morphometric characteristics of the vessels of olfactory bulbs in albino rat early postnatal ontogenesis, the study was performed using the histochemical method for demonstration of alkaline phosphatase activity, which is a marker of vascular endothelium, and vessel diameter and relative density were measured during the first three months of life. Desympathization was induced in rats by daily intraperitoneal injection of 60-70 mg/kg of guanethidine during postnatal days 1 to 30. The vessel diameter was found to increase after day 30 simultaneously with the changes of the vascular wall of vessels (irregular contour and non-uniform vasodilatation, non-uniform decrease in alkaline phosphatase activity).