Publications by authors named "M N Labour"
Article Synopsis
- Researchers modified biobased polylactide (PLA) films by applying a low reticulate polysiloxane gel to enhance their surface properties, specifically making them more hydrophilic.
- The modification involved coating the PLA with poly(methylhydrogenosiloxane) (PMHS) and then incorporating hydrophilic molecules like triethylene glycol monomethyl allyl (TEGMEA) and a new zwitterionic compound for improved water interaction.
- Tests showed that the modified PLA films were much wetter (lower water contact angles) and maintained good biocompatibility, which reduces protein and bacterial adhesion, indicating their potential for medical applications.
Regenerative medicine based on cell therapy has emerged as a promising approach for the treatment of various medical conditions. However, the success of cell therapy heavily relies on the development of suitable injectable hydrogels that can encapsulate cells and provide a conducive environment for their survival, proliferation, and tissue regeneration. Herein, we address the medical need for cyto- and biocompatible injectable hydrogels by reporting on the synthesis of a hydrogel-forming thermosensitive copolymer.
View Article and Find Full Text PDFLiver tissue engineering approaches aim to support drug testing, assistance devices, or transplantation. However, their suitability for clinical application remains unsatisfactory. Herein, we demonstrate the beneficial and biocompatible use of porous pullulan-dextran hydrogel for the self-assembly of hepatocytes and biliary-like cells into functional 3D microtissues.
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- Synthetic 3D hydrogels are being studied for tissue regeneration, but their low vascularization limits long-term cell survival.
- Researchers created hydrogels resembling human blood vessels with diameters from 28 to 680 μm, enhancing endothelial cell adhesion through coated surfaces and structural modifications.
- The internal microarchitecture of polysaccharide-based hydrogels can promote endothelial cell behaviors such as adhesion and migration, demonstrating that geometry can significantly influence cell function for tissue engineering.
Bone formation or regeneration requires the recruitment, proliferation, and osteogenic differentiation of stem/stromal progenitor cells. A potent stimulus driving this process is mechanical loading. Osteocytes are mechanosensitive cells that play fundamental roles in coordinating loading-induced bone formation via the secretion of paracrine factors.
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