Publications by authors named "M N Kouakou"
Background And Hypothesis: Individuals with schizophrenia (SCZ) suffer from comorbidities that substantially reduce their life expectancy. Socioeconomic inequalities could contribute to many of the negative health outcomes associated with SCZ.
Study Design: We investigated genome-wide datasets related to SCZ (52 017 cases and 75 889 controls) from the Psychiatric Genomics Consortium, household income (HI; N = 361 687) from UK Biobank, and 2202 medical endpoints assessed in up to 342 499 FinnGen participants.
Background: There is still a limited understanding of the dynamics contributing to the comorbidity of COVID-19 and anxiety outcomes.
Methods: To dissect the pleiotropic mechanisms contributing to COVID-19/anxiety comorbidity, we used genome-wide data from UK Biobank (up to 420,531 participants), FinnGen Project (up to 329,077 participants), Million Veteran Program (175,163 participants), and COVID-19 Host Genetics Initiative (up to 122,616 cases and 2,475,240 controls). Specifically, we assessed global and local genetic correlation and genetically inferred effects linking COVID-19 outcomes (infection, hospitalization, and severe respiratory symptoms) to anxiety disorders and symptoms.
Article Synopsis
- Researchers examined how ADHD relates genetically to various substance use disorders (SUDs) using data from large genome-wide association studies (GWAS).
- They found strong genetic correlations between ADHD and SUDs like cannabis and opioid use disorder, as well as problematic alcohol and tobacco use, with a notable pleiotropic SNP indicating shared genetic factors.
- The study suggests that SUDs, particularly problematic alcohol and tobacco use, have a stronger causal effect on ADHD than vice versa, highlighting complex genetic links and shared risk factors contributing to their comorbidity.
In recent years, jassids have become a real problem for cotton growing in Ivory Coast. It is important to investigate the causes of this problem. The aim of this study was to highlight the diversity of jassid species and their impact on cotton growing in Ivory Coast.
View Article and Find Full Text PDFImportance: Posttraumatic stress disorder (PTSD) has been reported to be a risk factor for several physical and somatic symptoms. However, the genetics of PTSD and its potential association with medical outcomes remain unclear.
Objective: To examine disease categories and laboratory tests from electronic health records (EHRs) that are associated with PTSD polygenic scores.