Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics.

Higher brain functions require flexible integration of information across widely distributed brain regions depending on the task context. Resting-state functional magnetic resonance imaging (fMRI) has provided substantial insight into large-scale intrinsic brain network organisation, yet the principles of rapid context-dependent reconfiguration of that intrinsic network organisation are much less understood. A major challenge for task connectome mapping is the absence of a gold standard for deriving whole-brain task-modulated functional connectivity matrices.

Comparison of whole-brain task-modulated functional connectivity methods for fMRI task connectomics.

Higher brain functions require flexible integration of information across widely distributed brain regions depending on the task context. Resting-state functional magnetic resonance imaging (fMRI) has provided substantial insight into large-scale intrinsic brain network organisation, yet the principles of rapid context-dependent reconfiguration of that intrinsic network organisation are much less understood. A major challenge for task connectome mapping is the absence of a gold standard for deriving whole-brain task-modulated functional connectivity matrices.

To lie or to tell the truth? The influence of processing the opponent's feedback on the forthcoming choice.

Introduction: The brain mechanisms of deceptive behavior are relatively well studied, and the key brain regions involved in its processing were established. At the same time, the brain mechanisms underlying the processes of preparation for deception are less known.

Methods: We studied BOLD-signal changes during the presentation of the opponent's feedback to a previous deceptive or honest action during the computer game.

Dark triad personality traits are associated with decreased grey matter volumes in 'social brain' structures.

Introduction: Personality traits and the degree of their prominence determine various aspects of social interactions. Some of the most socially relevant traits constitute the Dark Triad - narcissism, psychopathy, and Machiavellianism - associated with antisocial behaviour, disregard for moral norms, and a tendency to manipulation. Sufficient data point at the existence of Dark Triad 'profiles' distinguished by trait prominence.

Impaired Non-Selective Response Inhibition in Obsessive-Compulsive Disorder.

Two prominent features of obsessive-compulsive disorder (OCD) are the inability to inhibit intrusive thoughts and behaviors and pathological doubt or intolerance of uncertainty. Previous study showed that uncertain context modeled by equiprobable presentation of excitatory (Go) and inhibitory (NoGo) stimuli requires non-selective response inhibition in healthy subjects. In other words, it requires transient global inhibition triggered not only by excitatory stimuli but also by inhibitory stimuli.