High temporal variability not trend dominates Mediterranean precipitation.

State-of-the-art climate models project a substantial decline in precipitation for the Mediterranean region in the future. Supporting this notion, several studies based on observed precipitation data spanning recent decades have suggested a decrease in Mediterranean precipitation, with some attributing a large fraction of this change to anthropogenic influences. Conversely, certain researchers have underlined that Mediterranean precipitation exhibits considerable spatiotemporal variability driven by atmospheric circulation patterns maintaining stationarity over the long term.

Black raspberry seed oil - Chemical composition, antioxidant/antimicrobial activities and in vitro wound-healing potential.

This study aimed to perform chemical characterization of black raspberry seed oil (Rubus occidentalis L., Rosaceae) from Serbia in terms of fatty acids and tocols composition, total carotenoid content, as well as to investigate its antioxidant/antimicrobial activities and in vitro wound-healing potential. GC/MS analysis revealed that linoleic (39.

Analytical and Clinical Validation of Solo-Test Driver: A Targeted Amplicon-Based NGS Test-System for FFPE and cfDNA Analysis in Clinical Oncology Setting.

Background: Next-generation sequencing (NGS) is increasingly integrated into cancer patient management, necessitating cost-effective, reliable tests for companion diagnostics. We present the validation of the Solo-test Driver panel, a custom NGS amplicon-based tool for DNA analysis of 34 oncogenes, addressing key clinical needs.

Methods: The panel's performance was validated for detecting SNVs, CNVs, and MSI.

and Are Putative Progenitor Markers That Are Localized in the Perivascular Adventitia of the Adult Monkey Brain Subventricular Niche.

The largest area in the adult mammalian brain that contains stem and progenitor cells at different stages of differentiation is the subventricular zone located along the lateral wall of the lateral ventricle. We have previously shown in adult monkeys that transient global cerebral ischemia upregulates the expression of hundreds of genes in this zone, including genes known to be related to stemness in the rodent brain. Here, we analyzed the immunophenotype of two of these genes, and , by co-expression experiments, applying a panel of known stem/progenitor-cell-related markers.

Modified Decision Tree with Custom Splitting Logic Improves Generalization across Multiple Brains' Proteomic Data Sets of Alzheimer's Disease.

Many factors negatively affect a generalization of the findings in discovery proteomics. They include differentiation between patient cohorts, a variety of experimental conditions, etc. We presented a machine-learning-based workflow for proteomics data analysis, aiming at improving generalizability across multiple data sets.