[The determination of specific Pseudomonas aeruginosa antitoxins in commercial preparations of human immunoglobulin].

The comparative study of the activity of P. aeruginosa specific antitoxins in 134 lots of commercial preparations of human immunoglobulin in parallel mouse experiments on the neutralization of the lethal effect of exotoxin and in ELISA made it possible to establish a high degree of correlation between their results and the possibility of using immunochemical assays instead of biological tests in the large-scale production of anti-P. aeruginosa immunoglobulin.

[Pseudomonas aeruginosa toxoid].

P. aeruginosa adsorbed toxoid has been obtained. The stabilization of exotoxins and the content of proteases, hemolysin, lecithinase in their structure have been found to enhance the immunogenic potency of preparations which protect test animals from death caused by the experimental injections of toxins, homologous and heterologous to bacterial strains of different O-serogroups, into these animals.

[Antibodies against Pseudomonas aeruginosa toxin in preparations of normal human immunoglobulin].

Some lots of commercial normal human immunoglobulin have been found to contain antibodies neutralizing the action of P. aeruginosa exotoxin. The content of antibodies in human immunoglobulin preparations correlates to a certain degree with their protective activity determined in the passive protection test in white mice.

[Pseudomonas aeruginosa exotoxin].

Different P. aeruginosa strains have been found to differ in exotoxin synthesis. The strain isolated at the Mechnikov Research Institute for Vaccines and Sera (Moscow) and newly isolated cultures obtained from patients with the severe course of the infectious process have been found to possess the highest toxigenic activity and to synthesize exotoxins with the most complete set of pathogenically important antigens.

[Antigens of Shigella dysenteriae serovars 3-7. IV. Immunochemical study of the exotoxin].

The exotoxins of Sh. dysenteriae, serovars 3 and 7, possess antigenic and serological properties and are characterized by the heterogeneous antigenic structure which distinctly differs from the structure of O-antigen in its immunochemical properties. These exotoxins consist of thermolabile and thermostable components.