Publications by authors named "M N Graves"
Background: There is a shortage of equine veterinarians. Understanding what factors are associated with job satisfaction in equine veterinarians can inform interventions to increase retention in equine medicine.
Objective: To explore the prominent factors causing work dissatisfaction and burnout in equine veterinarians.
Article Synopsis
- - A new low-rank reconstruction technique has been introduced to fill in missing samples during the dead-time gap in Zero Echo Time (ZTE) imaging.
- - The method treats the missing data as an inverse problem, and tests show that it performs better than traditional methods when evaluated through simulations and in vivo experiments.
- - This approach successfully reconstructs images artifact-free for dead-time gaps of up to 4 Nyquist dwells, improving imaging bandwidth effectiveness compared to standard algebraic and parallel imaging techniques.
Article Synopsis
- Hyperpolarized carbon-13 (C) MRI can non-invasively evaluate how the brain metabolizes [1-C]pyruvate, revealing insights about enzymatic activities beyond the commonly studied lactate dehydrogenase (LDH) and pyruvate dehydrogenase (PDH).
- After injecting hyperpolarized pyruvate, researchers detected cerebral carbon dioxide (CO) and bicarbonate (HCO3), allowing for brain pH measurements, which averaged 7.40 in a small sample of volunteers, indicating the method's reliability.
- The study also identified hyperpolarized [1-C]aspartate and alanine, suggesting additional metabolic pathways and localization of alanine to skeletal muscle, emphasizing
Article Synopsis
- Myosin-7A (Myo7A) is a critical motor protein that helps organize stereocilia in inner ear hair cells, playing a key role in hearing.
- Mutations in Myo7A are linked to various genetic hearing loss conditions, particularly autosomal dominant DFNA11 deafness, but the structural aspects governing its motor functions are not fully understood.
- This study used cultured kidney cells to identify mutations that enhance Myo7A's targeting to cell surfaces, showing that specific IQ motifs in its structure are crucial for this process, and confirming that some DFNA11 mutations may lead to increased targeting, contributing to the genetics of this hearing loss.
Aims: While acute cardiovascular complications of coronavirus disease 2019 (COVID-19) are well described, less is known about longer-term cardiac sequelae. For many individuals with cardiac signs or symptoms arising after COVID-19 infection, the aetiology remains unclear. We examined immune profiles associated with magnetic resonance imaging (MRI) abnormalities in patients with unexplained cardiac injury after COVID-19.
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