Clinical significance of stratifying prostate cancer patients through specific circulating genes.

Patient stratification remains a challenge for optimal treatment of prostate cancer (PCa). This clinical heterogeneity implies intra-tumoural heterogeneity, with different prostate epithelial cell subtypes not all targeted by current treatments. We reported that such cell subtypes are traceable in liquid biopsies through representative transcripts.

Standing or Very Low-Intensity Cycling as Sedentary Breaks: Does Physical Activity Level Matter?

Background: Active breaks and very low- to low-intensity exercises such as walking or cycling at an active desk have been shown to significantly counteract the negative effect of prolonged sedentary behaviors. The objective was to investigate the effect of physical activity level (PAL) on changes in energy expenditure (EE), heart rate, and substrate oxidation from sit-to-stand and sit-to-light cycling.

Methods: Fifty healthy young males and females (age: 23.

Acute simulated weight gain might not increase the energy cost of walking in adolescents with obesity.

Introduction: This work aims at evaluating the adaptations of the energy cost of walking (Cw) to simulated weight gain at different walking speeds in adolescents with obesity.

Methods: Substrate use and Cw were evaluated during a graded walking exercise (4 × 5min at 0.75, 1, 1.

Original salivary sex hormone data of naturally menstruating athletes and hormonal contraceptive users.

Objectives: There is a lack of data on salivary sex hormones across the menstrual cycle (MC) or hormonal contraceptive (HC) cycle of elite athletes. We aimed to provide original data on salivary sex hormones (17β-estradiol, progesterone and free testosterone) in naturally menstruating female athletes with a regular cycle or irregular cycle and using combined HC. A secondary purpose was to compare these data with published data from the general population according to the menstrual status (MC or HC or irregularly menstruating).

Screening for Frailty According to Rural and Suburban Health Areas in the Context of Adapted Integrated Care for Older People Approach: The FRAGING Study.

Background: The integrated care for older people (ICOPE) program, developed by the World Health Organization, serves as a public health initiative to maintain older adults' functional abilities and promote healthier aging. Here, we adapted the ICOPE approach to assess overall prevalence of frailty in rural and semi-urban areas. We also investigated health-related quality of life and physical activity and sedentary behavior in older people.