Publications by authors named "M N Dickler"
Article Synopsis
- GDC-0927 is a new oral medication designed to target and degrade estrogen receptors, showing potential in treating ER+ breast cancer by inducing tumor regression in lab models.
- In a phase I study involving postmenopausal women with metastatic breast cancer, the drug was found to be safe, with common side effects including nausea and fatigue, but no severe adverse events or deaths reported.
- Although no complete or partial tumor responses were observed, about 29% of patients experienced clinical benefits, with significant reductions in estrogen receptor activity that suggest the drug successfully engages its target.
Germline variants might predict cancer progression. Bevacizumab improves overall survival (OS) in patients with advanced cancers. No biomarkers are available to identify patients that benefit from bevacizumab.
View Article and Find Full Text PDFPurpose: Endocrine therapy (ET) is an effective strategy to treat hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC) but nearly all patients eventually progress. Our goal was to develop and validate a web-based clinical calculator for predicting disease outcomes in women with HR+ABC who are candidates for receiving first-line single-agent ET.
Methods: The meta-database comprises 891 patient-level data from the control arms of five contemporary clinical trials where patients received first-line single-agent ET (either aromatase inhibitor or fulvestrant) for ABC.
Little is known regarding the brain substrates of Gambling Disorder, including surface brain morphometry, and whether these are linked to the clinical profile. A better understanding of the brain substrates will likely help determine targets to treat patients. Hence, the aim of this study was two-fold, that is to examine surface-based morphometry in 17 patients with gambling disorder as compared to norms of healthy individuals (2713 and 2790 subjects for cortical and subcortical anatomical scans, respectively) and to assess the clinical relevance of morphometry in patients with Gambling Disorder.
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