First wheat certified reference material for organically bound tritium measurement in the environment.

Measuring the radioactivity of organically bound tritium in environmental samples is difficult. For the past twenty years, many laboratories have been working on the development of reliable tritium measurement methods. In this context, several interlaboratory comparisons have been organised to develop these methods and enable laboratories to compare themselves.

Controlled Potential Coulometry for the accurate determination of plutonium in the presence of uranium: The role of sulfate complexation.

Controlled Potential Coulometry (CPC) is generally regarded as one of the most accurate analytical methods available for the quantification of plutonium (Pu) in acidic aqueous solutions. With a growing use of mixed oxide nuclear fuel, there has been an interest in the technique's applicability to the analysis of Pu in the presence of uranium (U). Expanding on previous studies, the work presented herein demonstrates the highly accurate CPC analysis of Pu in mixed solutions (Pu + U) containing large quantities of U (U:Pu up to 100:1) as well as establishing the role played by sulfate anions during the analyses.

Synthesis and in vitro evaluation of new 5-substituted 6-nitroimidazooxazoles as antikinetoplastid agents.

In continuation of our pharmacomodulation work on the nitroimidazooxazole series, we report the synthesis of new 5-substituted 6-nitroimidazooxazole derivatives. Our aim was to evaluate how functionalization of the 5-position of the 6-nitroimidazooxazole scaffold affects antileishmanial and antitrypanosomal in vitro activities. Twenty-one original compounds were synthesized and evaluated for their in vitro antileishmanial (L.

2,4-Disubstituted 5-Nitroimidazoles Potent against Clostridium difficile.

Metronidazole is one of the first-line treatments for non-severe Clostridium difficile infections (CDI). However, resistance limits its use in cases of severe and complicated CDI. Structure-activity relationships previously described for the 5-nitroimidazole series have shown that functionalization at the 2- and 4-positions can impart better activity against parasites and anaerobic bacteria than metronidazole.