[Non-developing pregnancy: histological and immunohistochemical markers of endocrine disorders in endometrial scrapes].

Histological and immunohistological (monoclonal antibodies against desmin, vimentin, glycodelin, IGFBP-1, estrogen receptors and progesterone receptors) studies were carried out to examine uterine scrapes from 47 healthy women - medical abortions from 6 to 10 weeks of conception and from 44 patients after non-developing pregnancy in the first trimester (recurrent miscarriage), which had been induced by verified endocrine disorders. Among them, three isolated pathogenetic types were identified: 1) uterine gland retardation as preserved islets of cylindrical glands with a narrow lumen or, on the contrary, areas with enlarged glands and atrophic epitheliocytes; immunohistochemically, they exhibited a drastic reduction in the expression of glycodelin, the major local immunosuppressor; 2) incomplete decidualization when it in the presence of progesterone deficiency was delayed at the state of predecidual and decidual cells retaining the smooth muscle cell marker - desmin; 3) verified progesterone receptor insufficiency. Each of the given clinical and morphological types of endocrine causes of non-developing pregnancy requires that an individual approach be applied to examining and treating these patients.

[Glycodelin as a potential marker of female genital system tumors (a review of literature)].

The authors present the currently available data on the expression of glycodelin, a unique secretory protein of the human reproductive system, which has gender-dependent glycosylation, immunosuppressive and morphogenetic activities, in gynecological cancers. They also discuss the theoretical and practical aspects of studying glycodelin as an effector and a marker molecule of oncogenesis.

[Fertility alpha-2-microglobulin expression in the human bulbourethral glands].

Fertility alpha-2-microglobulin (FAMG) was demonstrated in the human bulbourethral glands by the method of indirect immunoperoxidase staining using monoclonal antibodies against FAMG. The product of the immunohistochemical reaction was primary found in the duct cells. Weak immunopositive reaction was observed in single epitheliocytes of the secretory units.

[Expression of endometrial proteins in the uterine glands in physiological and non-developing pregnancy].

It is established that at the 1st trimester of the progressing pregnancy uterine glands produce both endometrial proteins (placental al-microglobulin--PAMG) and alpha 2-fertility microglobulin (AFMB) but with different intensity: maximum level of PAMG is at early periods (4-5 weeks) but 8-9 weeks of gestation for AFMB. Production deficiency of PAMG and AFMB in the glands epithelium is found in 90% cases of non-developing pregnancy (4-7 weeks) and this is obviously one of the causes of early pregnancy interruption.