Prospects of e-Coaching as a Platform for Empowering Families of Person With Mental Disorder: A Qualitative Study.

Introduction: In all countries, the burden of mental disorders (MDs) spans the entire life course. Smartphones are currently widely used by families with a history of MD looking for the required mental health information. The use of digital media is an alternative to improving the ability of families to care for person with MD at home.

A Modified EMD Technique for Broken Rotor Bar Fault Detection in Induction Machines.

Induction machines (IMs) are commonly used in various industrial sectors. It is essential to recognize IM defects at their earliest stage so as to prevent machine performance degradation and improve production quality and safety. This work will focus on IM broken rotor bar (BRB) fault detection, as BRB fault could generate extra heating, vibration, acoustic noise, or even sparks in IMs.

BTLA and PD-1 signals attenuate TCR-mediated transcriptomic changes.

T cell co-inhibitory immune checkpoints, such as PD-1 or BTLA, are bona fide targets in cancer therapy. We used a human T cell reporter line to measure transcriptomic changes mediated by PD-1- and BTLA-induced signaling. T cell receptor (TCR)-complex stimulation resulted in the upregulation of a large number of genes but also in repression of a similar number of genes.

Extraneural infection route restricts prion conformational variability and attenuates the impact of quaternary structure on infectivity.

Prions can exist as different strains that consist of conformational variants of the misfolded, pathogenic prion protein isoform PrPSc. Defined by stably transmissible biological and biochemical properties, strains have been identified in a spectrum of prion diseases, including chronic wasting disease (CWD) of wild and farmed cervids. CWD is highly contagious and spreads via direct and indirect transmission involving extraneural sites of infection, peripheral replication and neuroinvasion of prions.